What's the source of Imanis's transgenes?
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|
Transgene |
Accession # |
Gene Source |
Description |
|---|---|---|---|
|
Luc2 |
AY738222 |
Photinus pyralis |
Luciferase codon optimized by Promega1. |
|
hNIS |
U66088 |
Homo sapiens |
Transient NIS expression induces iodide uptake2. |
|
hNIS I147V |
Mutant of U66088 |
Homo sapiens |
NIS genetically modified by Imanis for enhanced uptake. |
|
mNIS |
AF235001 |
Mus musculus |
Transient expression induces iodide uptake3. |
|
rNIS |
U60282.1 |
Rattus norvegicus |
Transient expression induces iodide uptake4. |
|
pigNIS |
NM214410 |
Sus scrofa |
Transient expression induces iodide uptake5. |
|
RhNIS |
N/A* |
Rhesus macaque |
Transient expression induces iodide uptake. |
|
dNIS |
XM_541946 |
Canis lupus |
Transient expression induces iodide uptake6. |
|
IRES |
M81861 (nt 260 to 848) |
EMCV |
Independent translation of multiple proteins from a single transcript7. |
|
eGFP |
AAB02572.1 |
Variant of GFP from Aequorea victoria |
100-fold increase in green fluorescent signal as compared to GFP8 |
|
iRFP |
JN247409 |
Rhodopseudomonas palustris |
Near-infrared fluorescent protein: excitation = 690 emission = 713 nm9. |
|
dsRed |
AB212907 |
Anopheles gambiae |
Red fluorescent protein variant10 |
|
DRD2 |
NM_016574.3 |
Homo Sapiens |
GPCR, dopamine receptor variant found in the brain11. |
|
hNET |
NM_001172501.1 |
Homo Sapiens |
Sodium:neurotransmitter symporter family. Expressed by noradrenergic neurons12. |
|
SSTR2 |
AY236542.1 |
Homo Sapiens |
Somatostatin receptor. Highest expression in cerebrum and kidneys13. |
|
HSV-TK |
JQ352282.1 |
HSV |
Human herpesvirus 1 thymidine kinase (UL23)14. |
|
hTYR |
M27160.1 |
Homo sapiens |
Tyrosinase converts tyrosine to brown-pigmented melanin15 |
1 Promega
2 Smanik et al. Biochem Biophys Res Commun. 1996. 226(2):339-45
3 Pinke et al. Thyroid. 2001. 11(10):935-9
4 Dai et al. Nature. 1996. 379(6564):458-60
5 Selmi-Ruby et al. Endocrinology. 2003. 144(3):1074-85
6 Uyttersprot et al. Mol Cell Endocrinol. 1997. 131(2):195-203
7 Gurtu et al. Biochem Biophys Res Commun. 1996. 229(1):295-8
8 Cormack et al. Gene. 1996. 173(1):33-8
9 Filonov et al. Nat Biotechnol. 2011. 29(8):757-61
10 Baird et al. Proc Natl Acad Sci USA. 2000. 97(22):11984-9
11 Dearry et al. Cell Mol Neurobiol. 1991. 11(5):437-53
12 Pacholczyk et al. Nature. 1991. 350(6316):350-4
13 Parry et al. Mol Imaging. 2007. 6(1):56-67
14 Koehne et al. Nat Biotechnol. 2003. 21(4):405-13
15 Takeda et al. Biochem Biophys Res Commun. 1989. 162(3):984-90