{"product_id":"g-link","title":"G-Link CD3","description":"\u003cp\u003eG-link CD3 is a precision-engineered adapter protein that retargets lentiviral vectors (LV) to CD3, activating T cells and enhancing transduction in a single-step.\u003c\/p\u003e\n\u003cp\u003e[su_button url=\"#cellective_products\" style=\"flat\" size=\"5\" bold=\"yes\"]See Our Product Offerings[\/su_button]\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003eHow it Works:\u003c\/strong\u003e\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003eThe G-Link CD3 adapter protein binds to wild-type VSV-G on the surface of LV particles and retargets them to CD3. In addition to G-binding and CD3-retargeting domains, the G-Link CD3 adapter protein includes a trimerizing linker, enabling high-avidity attachment to G. The adapter protein is designed to release in the endosome, allowing normal cell membrane fusion and cell transduction.\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"aligncenter wp-image-4508 size-large\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.20-PM-1024x712.jpeg\" alt=\"\" width=\"640\" height=\"445\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\u003cstrong\u003ePrecision Targeting:\u003c\/strong\u003e\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW100689075 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW100689075 BCX0\"\u003eG-Link CD3 enables selective transduction of CD3-positive T cells. The G-Link CD3-targeting domain binds specifically to CD3 to mediate T-cell binding, while the G-binding domain not only anchors G-Link CD3 to G but also prevents G from binding to its natural receptors and the trimerizing linker enhancers overall adapter stability. Together, these components \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW100689075 BCX0\"\u003emask entry \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW100689075 BCX0\"\u003ethrough native receptors \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW100689075 BCX0\"\u003ewhile retargeting delivery to CD3\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW100689075 BCX0\"\u003e.\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW100689075 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"wp-image-4509 size-large alignleft\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.21-PM-1024x403.jpeg\" alt=\"\" width=\"640\" height=\"252\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW242918095 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003eGFP-encoding \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003eLV\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e \u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW242918095 BCX0\"\u003epseudotyped\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e with VSV-G was used directly or following retargeting with G-Link\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e CD3 \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003eto transduce \u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW242918095 BCX0\"\u003eJurkat\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e (CD3+)\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e and \u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW242918095 BCX0\"\u003eJurkat\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e-TCR-KO\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e (CD3-)\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e cells. \u003c\/span\u003e\u003cspan class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW242918095 BCX0\"\u003eGFP\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003esignal in the cells \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003ewas\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW242918095 BCX0\"\u003e imaged (left) and quantitated (right) 3 days post transduction.\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW242918095 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e\n\u003cspan class=\"TextRun MacChromeBold SCXW188751346 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW188751346 BCX0\"\u003eEnhanced\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW188751346 BCX0\"\u003e Transduction \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW188751346 BCX0\"\u003eof Resting T Cells\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW188751346 BCX0\"\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW188751346 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW184822495 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW184822495 BCX0\"\u003eG-Link CD3 boosts transduction of resting T \u003c\/span\u003e\u003cspan class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW184822495 BCX0\"\u003ecells\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW184822495 BCX0\"\u003e simplifying workflows. \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW184822495 BCX0\"\u003eLVs retargeted using G-Link CD3 effectively transduce and active T-cells in one-step, so PBMCs can be transduced without the need for pre-activation using beads or cytokine cocktails. \u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW184822495 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"wp-image-4511 aligncenter\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.25-PM-400x242.jpeg\" alt=\"\" width=\"600\" height=\"363\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW21266400 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003eResting h\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003euman PBMCs were transduced at 1000 LVP\/cell with GFP-encoding (top) or BCMA-CAR-encoding (bottom) \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003eLVs\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003e \u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW21266400 BCX0\"\u003epseudotyped\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003e with VSV-G. \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003eLVs\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21266400 BCX0\"\u003e were used directly (left) or retargeted using G-link (right).\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW21266400 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"wp-image-4514 size-large aligncenter\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.35-PM-1024x473.jpeg\" alt=\"\" width=\"640\" height=\"296\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW135837156 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003ePBMCs were incubated with \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003eVSV-G-\u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW135837156 BCX0\"\u003epseudotyped\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e LV\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e (left), VSV-G-\u003c\/span\u003e\u003cspan class=\"NormalTextRun SpellingErrorV2Themed SCXW135837156 BCX0\"\u003epseudotyped\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e lentivirus retargeted with G-Link\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e CD3\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e (middle), or G-Link\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e CD3\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e only (right). The T-cell activation marker CD25 was measured \u003c\/span\u003e\u003c\/span\u003e\u003cstrong\u003e\u003cspan class=\"TextRun Highlight SCXW135837156 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003eXX\u003c\/span\u003e\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"TextRun SCXW135837156 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e days after transduction\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW135837156 BCX0\"\u003e.\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW135837156 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2\u003e \u003c\/h2\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003e \u003c\/h2\u003e\n\u003ch2\u003e\n\u003cspan class=\"TextRun MacChromeBold SCXW164713692 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW164713692 BCX0\"\u003eTargeted In Vivo Delivery\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW164713692 BCX0\"\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW164713692 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW82005338 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW82005338 BCX0\"\u003eG-Link CD3-retargeted LVs work \u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"TextRun SCXW82005338 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW82005338 BCX0\"\u003ein vivo\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"TextRun SCXW82005338 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW82005338 BCX0\"\u003e to target and transduce T cells. \u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW82005338 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cimg class=\"alignleft wp-image-4513\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.35-PM-1-400x303.jpeg\" alt=\"\" width=\"600\" height=\"455\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"TextRun SCXW21709382 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003eNSG DKO mice bearing BCMA+ OPM2-luciferase tumors were humanized PBMCs. One week later\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003e (Day 0)\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003e, mice were injected via tail vein with\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003e saline control, G-Link CD3 only, or BCMA-CAR encoding LV retargeted with G-Link CD3. Tumor burden was \u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003emonitored\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003e over time by bioluminescence imaging.\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW21709382 BCX0\"\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW21709382 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 id=\"cellective_products\" style=\"color: white;\"\u003eProduc\u003c\/h4\u003e\n\u003ch2\u003e\n\u003cspan class=\"TextRun MacChromeBold SCXW245150389 BCX0\" lang=\"EN-US\" data-contrast=\"auto\"\u003e\u003cspan class=\"NormalTextRun SCXW245150389 BCX0\"\u003eThe G-Link CD3 Workflow\u003c\/span\u003e\u003cspan class=\"NormalTextRun SCXW245150389 BCX0\"\u003e:\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"EOP Selected SCXW245150389 BCX0\" data-ccp-props=\"{}\"\u003e \u003c\/span\u003e\n\u003c\/h2\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cimg class=\"aligncenter size-large wp-image-4512\" src=\"https:\/\/imanislife.com\/wp-content\/uploads\/2026\/05\/Image-5-10-26-at-2.37-PM-1024x256.jpeg\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Imanis Life Sciences","offers":[{"title":"Frozen \/ Standard","offer_id":52506148241589,"sku":"GLCD3-1","price":895.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/imanis-life-sciences-4.myshopify.com\/products\/g-link","provider":"Imanis Life Sciences","version":"1.0","type":"link"}