Stable, high reporter gene expression 

All our lentiviruses are pseudotyped with VSV.G protein, facilitating efficient transduction of diverse cell types across multiple species. When transduced into cells, the lentivirus transgenes integrate into the target cell genome resulting in stable reporter gene expression. Most of our lentiviruses utilize the spleen focus-forming virus (SFFV) promoter for constitutive, high-level reporter gene expression in a wide-variety of mammalian cells. Compared to other commonly-used promoters, such as the cytomegalovirus (CMV) promoter, the SFFV promoter is less susceptible to epigenetic silencing, making it a superior choice for longitudinal imaging in vivo.

Versatility 

Don’t be limited to a single transgene. Perform multi-modal imaging using one of our lentiviruses that encodes multiple reporter genes, such as enhanced green fluorescent protein (eGFP), firefly luciferase (Fluc), near-infrared fluorescent protein (iRFP), or the sodium iodide symporter (NIS). Or use one of our bicistronic lentiviruses that couples a reporter gene to an antibiotic resistance gene to select transduced populations enriched for high reporter gene expression. 

Quality and Safety

All our lentiviruses undergo rigorous quality control testing to ensure accurate titer, sterility, and robust transgene expression. And to increase biosafety, all our lentiviruses are self-inactivating.